ncRNA name | ILK siRNA |
ncRNA Category | siRNA |
Disease name | proliferative vitreoretinopathy (PVR) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line D407 |
Methods | siRNA transfection, qRT-PCR, Western blot, immunocytochemistry, MTT assay, immunofluorescence |
Expression pattern | associated |
Functional description | Targeting of ILK with a small interfering RNA not only inhibits human RPE cell attachment, spreading, migration and proliferation in vitro, but also effectively suppresses development of proliferative vitreoretinopathy in a rabbit model. |
PubMed ID | 18926819 |
Year | 2008 |
Title | Targeting of integrin-linked kinase with a small interfering RNA suppresses progression of experimental proliferative vitreoretinopathy. |
Drug-related ncRNA | NO |
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